Vaccine testing gone wrong!

wind2000 · Sep 22, 2007

promising experimental vaccine to prevent the AIDS virus has failed in a crucial experiment, with volunteers becoming infected with HIV anyway, leading the drug developer to halt the study.

Merck & Co. said Friday that it is ending enrolment and vaccination of volunteers participating in the international study, which is partly funded by the National Institutes of Health (NIH).

Officials at Merck told the Associated Press that 24 of 741 volunteers who got the vaccine in one segment of the trial later become infected with HIV, which causes AIDS.

In a comparison group of volunteers who got dummy shots, 21 of 762 participants also became infected with HIV.

"It's very disappointing news," said Keith Gottesdiener, head of Merck's clinical infectious disease and vaccine research group. "A major effort to develop a vaccine for HIV really did not deliver on the promise."

The study volunteers were all free of HIV at the start of the experiment. But they were at high risk for getting HIV: most were homosexual men or female sex workers. They were all repeatedly
counselled about how to reduce their risk of HIV infections, including use of condoms, according to Merck.

In a statement, the NIH said a data safety monitoring board, reviewing interim results, found the vaccine cannot be shown to prevent HIV infection or limit severity of the disease "in those who become infected with HIV as a result of their own behaviours that exposed them to the virus."

The Merck vaccine was the first major test of a new strategy to prevent HIV infection.

The first wave of attempts to develop a vaccine tried to stimulate antibodies against the virus, but that didn't work.

The new effort — and one being tried in most other current research — is aimed at making the body produce more of a crucial immune cell called killer T-cells. The goal is to simultaneously "train" those cells, like an army, to quickly recognize and destroy the AIDS virus when it enters cells in the bloodstream.

Merck and the HIV Vaccine Trials Network, an international collaboration of researchers and institutions, co-sponsored the study. The Merck vaccine was the farthest along of several in development, and this was the first large-scale test of it.

The experiment, called STEP, began in December 2004 and had enrolled 3,000 volunteers in Australia, Brazil, Canada, the Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico and the United States.

It aimed to determine if the vaccine, a shot made from a weakened cold virus that included bits of three HIV genes, could prevent HIV infection, or reduce the amount of HIV in the blood of infected people, or both.
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http://www.cbc.ca/health/story/2007/09/21/aids-vaccine.html

Must be rough for those who got infected. >.<

itzd0pey · Sep 22, 2007

ouch, but hey what if both sexes were whores/prostitutes =o if they didnt have hiv , they probably had herpes or w/e else =o

ah_wong201 · Sep 22, 2007

i hope those ppl who got infected didn't sign any waivers. if i was one of them i would sue the hell out of that company if i didn't sign a waiver.
thats fucked up

Knoctur_nal · Sep 22, 2007

damn..things really went wrong there...

fearless_fx · Sep 22, 2007

id hate to be the scientist who thought up this vaccine.

"oops, guess i dropped the ball on this one.. sorry u all have HIV now."

xiaojia · Sep 23, 2007

well.. they volunteered.. and there are always high risks involved in experiments.. buts its a pity cos their sacrifice wasnt paid off..

onelove · Sep 23, 2007

oh fck....so...they can't sue for damages or somethin? their life just got ruined ..=(

love`
mon

Vaccine testing gone wrong!

wind2000 Self Schemata

itzd0pey Well-Known Member

ah_wong201 Well-Known Member

Knoctur_nal |Force 10 from Navarone|

fearless_fx Eugooglizer

xiaojia Well-Known Member

onelove Well-Known Member